Board Thread:Spoilers!/@comment-4877635-20150304180627/@comment-24674051-20150430185937

Here's the thing. Yes, Gold's health will take a turn for the worst (since that is what the synopsis says). However, health turning for the worst can also make a person desperate. Isaac could see Gold's health turning, and look to someone else for help, but we need to remember that Isaac has his own agenda that we don't know about yet. So that is not going to help Gold, and the one thing we know is that Gold ALWAYS helps Gold.

I am going to guess that darkened savior's blood is needed for new ink (at least one version of it), and Gold decides that Lily might just be able provide some, since she has the darkness from Emma. And being desperate, he is going to approach Lily as someone that she knows (since I doubt that Lily is actually going to trust anyone). Regina is the best choice, becuase not only can Rumple get close, but he can make Regina look bad in the process.

Besides, even though we saw Regina in the Promo with the Author, she may also have her hands full dealing with Zelena.