Board Thread:Wiki-Related Discussion/@comment-25491743-20160803235426/@comment-24674051-20160805175027

Both should be sterile. But there is water from Lake Nostos available (I think that the water from the well serves as that, based on what both August and Gold said in Season 1), so there is no reason that one or both could not be cured, should there be a need from a story perspective.

However, Regina does have descendents already, even though she is sterile. Both Snow (Step-Daughter) and Henry (Adopted) would be considered descendents. So there are other ways of having descendants than natural birth.

And, no, I do not want to see what EQS having descendents would do to the already mixed up mess of the Charming/Mills/Swan/Stiltskin family.